Dr. Justyna Fert-Bober
I am an Assistant Professor at Cedars-Sinai Heart Institute, and my research is focused on molecular and cellular mechanisms of heart failure (HF) in general population and in the immunopathogenesis of heart disease in the rheumatoid arthritis (RA) patient. I have a broad background in biochemistry, with specific training and expertise in proteomics and mass spectrometry and secondary immunology research. I am a pioneer in the understanding of arginine deiminases and protein citrullination’s contribution to neo-antigens production. My lab is interested in targeting the citrullinated proteins associated with the HF disease and finding the functional significance at least, in a subset of biologically important modifiable cardiac proteins. I claim that cardiac specific citrullinated proteins yield neo-antigens production and can become additional targets in epitope spreading of autoimmune responses. This will allow to create new diagnostics and prognostic tests for clinical use.