HUPO 2021 World Congress

INTERACTIVE HOT TOPIC DISCUSSIONS

Interactive Hot Topic Discussions

HUPO 2021 ReCONNECT is introducing the new highly interactive Hot Topic Discussions with the aim to facilitate open discussions on current proteomics topics, from technical developments to HUPO affairs. These sessions will feature world renowned speakers who will briefly introduce the topic before answering questions from attendees in a casual and informal virtual setting.

  • NOVEMBER 17
  • NOVEMBER 18

16:00 - 17:00 (UTC) Hot Topic Discussion 1: Future Preparedness for Pandemics: Role of Proteomics & Multi-omics Technologies

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread throughout the globe. What has compounded the problem is the non-availability of robust detection methods as well as lack of knowledge of how to treat the disease. There has never been a more urgent situation ever before to review our preparedness for future pandemics. The panellist will discuss role of proteomics, multi-omics technologies, big data and ML for COVID-19 rapid detection methods, disease prognosis and therapeutic approaches.
Moderator: Sanjeeva Srivastava

Discussants: Joshua LaBaer, Graham Ball, Tiannan Guo, Shantanu Sengupta

16:00 - 17:00 (UTC) Hot Topic Discussion 2: Moms in Proteomics

Supporting women in STEM, and in particular, the rapidly expanding field of proteomics, needs to go beyond traditional methods of mentorship and promotion by recognizing and encouraging mothers to pursue careers in STEM. The intricate balance between managing a successful research program, writing grant applications, teaching and mentoring trainees, and fulfilling institutional and external service commitments, all while raising young children and caring for their needs, is demanding, challenging, and daunting for many women and mothers. This Hot Topic will provide an opportunity to connect with other mothers in STEM, share stories of success and failure, and build a network for success of mothers in highly productive and influential careers.

Moderator: Jennifer Geddes-McAlister

Discussants: Francesca Sacco, Maria Pavlou, Scarlet Koch, Natalie Krahmer, Ruth Hüttenhain

16:00 - 17:00 (UTC) Hot Topic Discussion 3: Standardization is Key

Reviewing the methods sections in published papers, it looks like everybody has their own standard or optimized solution. But the variety makes it difficult to reproduce the experiments, makes it harder to compare results, and slows down knowledge transfer. The question then is whether standardization will hurt innovation or enable a deeper focus on the biological mechanisms under study.

Moderator: Nicolai Bache

Discussants: Jennifer Van Eyk, Phil Robinson, Martin Overgaard, Nicolai Albrechtsen

23:00 - 00:00 (UTC) Hot Topic Discussion 4: Metaproteomics

Metaproteomics – measuring the composite proteome from multiple organisms in a community — touches upon all aspects of conventional proteomics workflows, but much more intensely. Real or perceived challenges that are uniquely related to metaproteomics can create obstacles for newcomers to this endeavor. We will discuss these obstacles – ranging from sample acquisition and storage to instrumentation and computational complexities – and how to approach them for applications related to human health and environmental studies.

Discussants: Daniel Figeys, Robert Hettich, Mary Lipton

23:00 - 00:00 (UTC) Hot Topic Discussion 5: Glycoproteomics Needs Glycobioinformatics

Recent developments in sample preparation, mass spectrometry and associated software tools facilitate the analysis of intact glycopeptides. However, bioinformatic tools for glycoproteomics are in their infancy compared to those available for more traditional proteomics, and considerable variation in performance metrics and interpretation currently exist among available tools and users. The lack of established guidelines and workflows for applying basic principles of glycobiology and tools for false-discovery rate estimation currently present challenges to accurate data reporting. In this session, experts in glycobiology and bioinformatics will discuss challenges and pose solutions to increase accuracy and reproducibility when interpreting mass spectrometry-based glycoproteomics data.

Moderator: Rebekah Gundry

Discussants: Frederique Lisacek, Robert Chalkley, Morten Andersen

23:00 - 00:00 (UTC) Hot Topic Discussion 6: Top-down MS and Native Proteomics

This session will focus on current challenges, applicable solutions, and future directions of top-down MS and native proteomics. Several proposed topics include native top-down, data analysis/statistics/quantitation, and application/sample preparation in top-down proteomics. We will have an open and robust discussion between the audience and the discussants (panelists) after a brief introduction of each topic from the moderator/discussant.

Moderator: Si Wu

Discussants: Ljiljiana Pasa-Tolic, Ying Ge, Neil Kelleher, Joseph Loo

23:00 - 00:00 (UTC) Hot Topic Discussion 7: Next Generation Proteomics Technologies: NGS, Microarray and Other Technology Platform Read Out

Discuss emerging proteomics technologies and their applications. What are the advantages and limitations of those technologies and future trending? What are the main application areas, what will be enabled by these technologies? How do these technologies add value to drug development pipelines?

Moderators: Fiona Kaper

Discussants: Towia Liberman, Carl Barrett, Adeeb Rahman

23:00 - 00:00 (UTC) Hot Topic Discussion 8: The Human Proteome Project Grand Project – Advancing the Human Proteome

Discussants: Charles Pineau, Gil Omenn, Robert Moritz, Ruedi Aebersold, Ileana Cristea, Cecilia Lindskog, Lydie Lane

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