HUPO 2021 World Congress

FULL HUPO 2021 PROGRAM

Please note that the program is subject to change without notice. All sessions are listed in Coordinated Universal Time (UTC). Please view the World Clock Converter for your timezone.

HUPO 2021 ReCONNECT is a fully virtual Congress.

Main Congress Program (Nov. 15-19)

  • NOV 15
  • NOV 16
  • NOV 17
  • NOV 18
  • NOV 19

11:30 - 12:30 (UTC)    HUPO Council Meeting Session 1 (By Invitation Only)

12:45 - 14:15 (UTC)    Opening Session & Plenary 1 (PL01) - Visualizing the Cell

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

For a complete understanding of a system's processes and each protein's role in health and disease, it is essential to study protein expression with a spatial resolution, as the exact location of proteins at the tissue, cellular or subcellular levels is tightly linked to protein function. This session highlights new discoveries and emerging efforts based on different spatial technologies.

Chairs: Stephen Pennington & Cecilia Lindskog

  • 12:45 Opening Remarks
    Yu-Ju Chen
  • 12:50 Introduction to the HUPO 2021 ReCONNECT Program and Virtual Platform
    Henning Hermjakob
  • 13:00 Highlights of the Year
    Benjamin Garcia
  • 13:05 PL01.01 Spatiotemporal Dissection of the Human Proteome
    Emma Lundberg
  • 13:35 PL01.02 The Dynamic Spatial Organisation of the Cell
    Kathryn Lilley
  • 14:05 Live Q&A

This session is sponsored by:      

14:30 - 15:45 (UTC)    Session 1 (KN01) - Combating COVID-19

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

COVID-19 infections have changed the world as we know it, possibly permanently in several ways. Research on coronaviruses has in record time led to a great understanding of the biology and pathogy of this modern-day plague, including the development of vaccines. Proteomics has been instrumental in our full understanding of this virus's mechanism and this session will highlight the latest proteomics research in this emergent area.

Chairs: Aleksandra Nita-Lazar & Mehdi Bouhaddou

  • 14:30 KN01.01 Glycomics of Sars-Cov-2: From Structural Biology to Vaccines
    Max Crispin
  • 14:50 KN01.02 Chasing SARS-CoV2 and Finding More
    Jennifer Van Eyk
  • 15:10 KN01.03 Profiling SARS-CoV-2 HLA-I Peptidome Reveals T Cell Epitopes From Out-of-Frame ORFs
    Susan Klaeger
  • 15:20 KN01.04 SARS-CoV-2 Structural Coverage Map Reveals Viral Protein Assembly, Mimicry, and Hijacking Mechanisms
    Sean O’Donoghue
  • 15:30 Live Q&A

This session is sponsored by:      

16:00 - 17:00 (UTC)     Mentoring Session (MS01) - How to Successfully Balance a Personal Life While in Academia

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

In addition to managing their daily lab work, young researchers are increasingly facing strenuous hurdles, such as maintaining a work-life balance, unclear career prospects, publication pressure, and writing blockades. Organized by HUPO’s Early Career Researcher Initiative in partnership with the European Proteomics Association’s Young Proteomics Investigators Club, the mentoring sessions extend the scope of HUPO ReCONNECT 2021 from pure science and technology to the topics that indirectly affect our research. 

Chairs: Maurine Fucito & Blandine Chazarin

Mentors:

  • Christine Carapito, University of Strasbourg
  • Harry Whitwell, Imperial College London
  • Jennifer Geddes-McAlister, University of Guelph

17:15- 18:15 (UTC)     Industry-Supported Seminar (ISS1) - ThermoFisher Scientific: Roadmap for Translational Proteomics Research and Precision Medicine 

Platform Location: Industry Hub | Industry Hub Auditorium 2

Please see here for more details.

 

 

17:15- 18:15 (UTC)     Industry-Supported Seminar (ISS2) - SCIEX: Powerful New Proteomic Workflows Enabled by the SCIEX ZenoTOF System

Platform Location: Industry Hub | Industry Hub Auditorium 1

Please see here for more details.

 

 

 

18:30 - 19:45 (UTC)     Session 2 (KN02) - Precision Pathology: Proteomics for Patients

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

Precision Medicine is now entering an era that reaches beyond genomics. Pathology, in particular, is transforming to diagnose the precise and quantitative changes of proteins as the machines of life and disease. Proteome-based diagnostic pathology will address crucial clinical needs, and there is an urgent need to develop stringent, fit-for-purpose proteomic assays that can be implemented in the clinic for the benefit of patients. This session will discuss high-impact clinical areas that will be transformed by proteomics and hopes to bring together physicians and scientists to drive this proteomic evolution of health care.

Chairs: Ed Nice & Justyna Fert-Bober

  • 18:30 KN02.01 Proteomics For Patients: How Proteomics Will Transform Medicine
    Michael Roehrl
  • 18:50 KN02.2 A Protein-Based Classifier for Thyroid Nodule Diagnosis
    Tiannan Guo
  • 19:10 KN02.03 Multiomics Identification and Validation of Novel Blood-Based Alzheimer’s Disease Autoantibody Biomarkers
    Miren Alonso-Navarro
  • 19:20 KN02.04 Beyond Fibril-Forming Proteins: Developing a More Holistic Approach on Amyloid Formation
    Juliane Gottwald
  • 19:30 Live Q&A

This session is sponsored by:   

20:00 - 21:00 (UTC)     Graduate Student Poster Competition

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

The graduate student poster competition serves as a platform to highlight the important contributions that graduate and PhD students make to the proteomics field. In this session eighth preselected finalists will present their posters and will be evaluated by an expert committee to select a winner and two runner-ups. Each presentation will consist of a 4min presentation and 2min Q&A.

Chairs: Giuseppe Palmisano & Jessica Brandi

  • 20:00 P11.17 MAGPIE: A Machine Learning Approach for Deciphering Protein-Protein Interactions in Human Plasma
    Emily Hashimoto-Roth
  • 20:06 P08.14 Identification of Protein Biomarkers in FFPE Primary Tissues to Predict Recurrence in Endometrial Cancer
    Carlos López Gil
  • 20:12 P11.42 SAPID-MSI: Spatially-Aware Protein Identification Algorithm for Mass Spectrometry Imaging
    Soroush Shahryari Fard
  • 20:18 P10.04 Cell Surface Phenotyping of the Human Heart Reveals Cardiomyocyte-Specific Targets and Surfaceome Dynamics of Explanted Cardiac Fibroblasts
    Linda Berg Luecke
  • 20:24 P12.C11 Data-Independent Acquisition Method for Ubiquitinome Analysis Reveals Regulation of Circadian Biology
    Fynn Hansen
  • 20:30 P08.12 Species-Specific Cutaneous Protein Signatures of Incision Injury and Correlation with Distinct Pain-Related Phenotypes in Humans
    Christin Kappert
  • 20:36 P10.09 The Proteomic Analysis of High Grade Serous Ovarian Cancer Reveals the Role of Tumor Microenvironment in Chemoresistance
    Kruttika Dabke
  • 20:42 Live Q&A

This session is sponsored by:

21:15 - 22:15 (UTC)     Industry-Supported Seminar  (ISS3) - BSI: Towards an In-depth Understanding of the HLA Immunopeptidome Using MS-based Workflows

Platform Location: Industry Hub | Industry Hub Auditorium 1

Please see here for more details.

 

 

 

 

23:00 - 00:00 (UTC)     HUPO Council Meeting Session 2 (By Invitation Only)

13:00 - 14:15 (UTC)     Plenary Session 2 (PL02) - Omics at Single-Cell Resolution

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

Single-cell omics is taking a quantum leap to dissect biology at individual cell resolution. This session will present emerging technologies and applications in single-cell omics.

Chairs: Catherine CL Wong & Blandine Chazarin

  • 13:00 PL02.01 Single Cell/Deep Visual Proteomics
    Matthias Mann
  • 13:30 PL02.02 Increasing the Sensitivity, Reliability, Reproducibility and Throughput of Single-Cell Proteomics
    Nikolai Slavov
  • 14:00 Live Q&A

This session is sponsored by:     

14:30 - 15:45 (UTC)    Session 3 (KN03) - Technological Advancements in Proteomics

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

This session will focus on new technologies for proteomics, highlighting improved ways to handle challenging samples, cutting-edge approaches and instrumentation for sample analysis, and enhanced strategies for data processing. Presentations will include examples of biological and/or clinical applications that illustrate the performance of the new technology.

Chairs: Gary Kruppa & Maurine Fucito

  • 14:30 KN03.01 Ultra-Fast Proteomics and How It Opens New Doors for Gene Function Prediction, Drug Screens, and Clinical Proteomics Using AI
    Markus Ralser
  • 14:50 KN0302 MONTE: A Multiomics Suite Enabling Serial Immunopeptidome, Ubiquitylome, Proteome, Phosphoproteome, Acetylome Analyses of Sample-Limited Tissues
    Steven Carr
  • 15:10 KN03.03 Next-generation Serology by Mass Spectrometry: Ig-MS Readout of the SARS-CoV-2 Antibody Repertoire
    Rafael Melani
  • 15:20 KN03.04 In-depth Plasma Proteomics Profiling with ProteographTM Product Suite: A Performance Evaluation of Label Free and TMT Multiplexing Approaches
    Alex Rosa Campos
  • 15:30 Live Q&A

16:00 - 17:00 (UTC)     Poster Session

Platform Location: Poster Sections 1 - 8

Poster presenters are available at their posters to present their work, chat with you and answer your questions.

View Full Poster List >>

17:15 - 18:15 (UTC)     Industry-Supported Seminar (ISS4) - Bruker: Advances in 4D-ProteomicsTM: Plasma Proteomics and Targeted Quantitative Biology

Platform Location: Industry Hub | Industry Hub Auditorium 1

Please see here for more details

 

17:15 - 18:15 (UTC)     Industry Supported Seminar (ISS5) - Biognosys: Unearth the Full Potential of DDA Proteomics with SpectroMine 3 

Platform Location: Industry Hub | Industry Hub Auditorium 2

Please see here for more details

20:00 - 21:00 (UTC)     HUPO General Assembly of Members Session 1

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

This is the annual meeting for active HUPO members. HUPO members are encouraged to attend for society updates, Council election results, to ask questions and play a fun Kahoot proteomics quiz at the end. Winners of the Kahoot quiz receive a 3-year HUPO membership, while the runner-up receives a 1-year HUPO membership. Download the Kahoot app ahead of time, or you can join the quiz via https://kahoot.it/.

Chairs: Yu-Ju Chen, HUPO President and Henning Hermjakob, HUPO Secretary General

21:15 - 22:15 (UTC)     ECR Networking Hour

Platform Location: ECR Lounge

The ECR Networking Hour is an open forum to bridge the digital, cultural, and continental gaps so that early-stage researchers can meet, share, and create bridges for future collaboration. Participants are encouraged to engage with their cameras and join in both the ice-breaker and proteomics-related networking. In preparation for the ECR Networking Hour, participants are encouraged to set up a LinkedIn or Twitter handle to keep the engagement going beyond November 16.

Chairs: Rob Rivers & Omar Mendoza Porras
Mentors are encouraged to attend

13:00 - 14:15 (UTC)    Plenary Session 3 (PL03) - Proteome-wide Structural Biology

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

A fundamental understanding of how proteins function in biology and disease requires a detailed characterization of their structures and the structural dynamics through protein interactions and post-translational modifications. This session will highlight emerging proteomics approaches to globally map protein structure alterations.

Chair: Juri Rappsilber & Ruth Ruth Hüttenhain

  • 13:00 PL03.01 3D Proteomics: From Structural to Functional Screens
    Paola Picotti
  • 13:30 PL03.02 Structural Biology on the Proteome-Wide Scale Using Protein Footprinting
    Lisa Jones
  • 14:00 Live Q&A

This session is sponsored by:     

14:30 - 15:45 (UTC)     
Session 4 (KN04) - Translating Proteomics into the Clinic

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

Proteomics has led to the discovery of new biomarkers in a wide range of diseases. This session will present new technologies to accelerate detection and prediction of diseases, and assay development from discovery to clinical use.

Chairs: Bernd Wollscheid & Chia Jung Yu

  • 14:30 KN04.01 Development and Delivery of Protein Biomarkers for Patient Benefit: “It’s Easy”
    Stephen Pennington
  • 14:50 KN04.02 Approach to Hypothesis Building from Multi-Omics Using Human Plasma Samples
    Yoshiya Oda
  • 15:10 KN04.03 Approaching a Non-invasive Diagnosis of Endometrial Cancer by the Analysis of Protein Biomarkers in Pap-Smears
    Eva Coll-de la Rubia
  • 15:20 KN04.04 Health Surveillance Panel Multiplexed MRM-Based Protein Assay for the Identification of Multiple Biomarkers of Disease Severity in Human Coronary Disease
    Esthelle Hoedt
  • 15:30 Live Q&A

This session is sponsored by:     

16:00 - 17:00 (UTC)   Hot Topic Discussion 1: Future Preparedness for Pandemics: Role of Proteomics & Multi-omics Technologies

Platform Location: Education Sessions & Recordings | Hot Topic Room Preparedness for Pandemics...

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread throughout the globe. What has compounded the problem is the non-availability of robust detection methods as well as lack of knowledge of how to treat the disease. There has never been a more urgent situation ever before to review our preparedness for future pandemics. The panellist will discuss role of proteomics, multi-omics technologies, big data and ML for COVID-19 rapid detection methods, disease prognosis and therapeutic approaches.

Moderator: Sanjeeva Srivastava

Discussants: Joshua LaBaer, Graham Ball, Tiannan Guo, Shantanu Sengupta

16:00 - 17:00 (UTC)     Hot Topic Discussion 2: Moms in Proteomics

Platform Location: Education Sessions & Recordings | Hot Topic Room Moms in Proteomics

Supporting women in STEM, and in particular, the rapidly expanding field of proteomics, needs to go beyond traditional methods of mentorship and promotion by recognizing and encouraging mothers to pursue careers in STEM. The intricate balance between managing a successful research program, writing grant applications, teaching and mentoring trainees, and fulfilling institutional and external service commitments, all while raising young children and caring for their needs, is demanding, challenging, and daunting for many women and mothers. This Hot Topic will provide an opportunity to connect with other mothers in STEM, share stories of success and failure, and build a network for success of mothers in highly productive and influential careers.

Moderator: Jennifer Geddes-McAlister

Discussants: Francesca Sacco, Maria Pavlou, Scarlet Koch, Natalie Krahmer, Ruth Hüttenhain

16:00 - 17:00 (UTC)     Hot Topic Discussion 3: Standardization is Key

Platform Location: Education Sessions & Recordings | Hot Topic Room Standardization is Key

Reviewing the methods sections in published papers, it looks like everybody has their own standard or optimized solution. But the variety makes it difficult to reproduce the experiments, makes it harder to compare results, and slows down knowledge transfer. The question then is whether standardization will hurt innovation or enable a deeper focus on the biological mechanisms under study.

Moderator: Nicolai Bache

Discussants: Jennifer Van Eyk, Phil Robinson, Martin Overgaard, Nicolai Albrechtsen

17:15 - 18:15 (UTC)    Industry-Supported Seminar (ISS6) - Olink: Exploring Molecular Phenotypes of Incident Breast Cancer Through Population-based Proteogenomics

Platform Location: Industry Hub | Industry Hub Auditorium 2

Please see here for more details.

 

17:15 - 18:15 (UTC)    Industry-Supported Seminar (ISS7) - Somalogic: New Insights and Discoveries from Massive Scale Proteomics

Platform Location: Industry Hub | Industry Hub Auditorium 1

Please see here for more details.

18:30 - 19:45 (UTC)     Session 5 (KN05) - Brain Rewiring in Neurological Disorders

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

As the world's population ages, age-related neurological disorders will continue to increase in numbers affected. Proteomics technologies will continue to play a central role in understanding how perturbations in protein modification, protein interactions, and localization in the brain propagate disease states. This session will illuminate recent findings that hold promise for new therapeutic targets and biomarkers.

Chairs: Renã A. S. Robinson & Ling Hao

  • 18:30 KN05.01 Mass Spectrometry in the Pandemic: Translation and Collaboration for Diagnostics and Prognostics
    Perdita Barran
  • 18:50 KN05.02 Using Large Data Approaches to Diagnose and Drug Dementia
    Judith Steen
  • 19:10 KN05.03 Parallel Proteomic and Microscopy Analyses Identify Protein Networks Associated with Synapse Loss Across Aging in the Human Brain
    Matthew MacDonald
  • 19:20 KN05.04 Proteomic/PTMomic Screening of Human Parkinson’s Disease IPSC-derived Neurons Identifies Disease Phenotypes and Potential Therapeutic Targets
    Helle Bogetofte
  • 19:30 Live Q&A

20:00 - 21:00 (UTC)     Mentoring Session (MS02) - Scientific Integrity

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

In addition to managing their daily lab work, young researchers are increasingly facing strenuous hurdles, such as maintaining a work-life balance, unclear career prospects, publication pressure, and writing blockades. Organized by HUPO’s Early Career Researcher Initiative in partnership with the European Proteomics Association’s Young Proteomics Investigators Club, the mentoring sessions extend the scope of HUPO ReCONNECT 2021 from pure science and technology to the topics that indirectly affect our research.

Chairs: Andreas Hober & Emily Hashimoto-Roth

Mentors: Stephen Pennington & Suzanne Farley & Anne-Claude Gingras

21:15 - 22:15 (UTC)    Industry-Supported Seminar (ISS8) - ThermoFisher Scientific: Post-translational Modifications - The Third Disruptive Wave in Proteomics

Platform Location: Industry Hub | Industry Hub Auditorium 2

Please see here for more details.

21:15 - 22:15 (UTC)    Industry-Supported Seminar (ISS9) - Seer: Advances in Untargeted Plasma Proteomics Analysis with the ProteographTM Product Suite

Platform Location: Industry Hub | Industry Hub Auditorium 1
Please see here for more details.

 

23:00 - 00:00 (UTC)     ECR Manuscript Competition

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

The manuscript competition serves as a platform to highlight the important contributions that postdoctoral fellows, young clinicians, and junior faculty members make to the proteomics field. In this session, three preselected finalists will present their publications and will be evaluated by an expert committee to select the "Proteomics Highlight of the Year". Each presentation will consist of a 12min talk and 8min live Q&A. Awards along with cash prizes ($1000 to winner, $500/each to two runners ups) will be presented to the finalists during the Closing Ceremony & Awards Session on November 19, 2021. In addition, the three finalists will receive complimentary registration for HUPO ReCONNECT 2021.

Chairs: Maike Langini & Christian Moritz & Rene Zahedi

  • 23:00 The Global Phosphorylation Landscape of SARS-CoV-2 Infection
    Mehdi Bouhaddou
  • 23:20 Benefits of Chemical Sugar Modifications Introduced by Click Chemistry for Glycoproteomic Analyses
    Stacy Malaker
  • 23:40 Global and Site-specific Effect of Phosphorylation on Protein Turnover
    Yansheng Liu

This session is sponsored by:

00:15 - 01:30 (UTC) Session 6 (KN06) - Proteomics-guided Therapeutics

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

Compared to gene-centric measurements, proteomics accurately reflects the action, mechanism, and effect of therapy. This session will highlight proteomics technologies to guide immuno-oncology, accelerate pharmaceutical research and development, and technological advancements in chemical proteomics.

Chairs: Bernhard Kuster & Teck Yew Low

  • 00:15 KN06.01 Insights into the Tumour Immunopeptidome and its Role in Personalized Immunotherapy
    Anthony Purcell
  • 00:35 KN06.02 Exploring Drug-Target Interaction Using Label-Free Darts and Lc-Ms/Ms. Method and Its Translational Impact
    Hojeong Kwon
  • 00:55 KN06.03 Proteomic Markers Predict Response to Methotrexate in Patients with Early Rheumatoid Arthritis
    Rocío Paz González
  • 01:05 KN06.04 Warp-speed Selectivity Profiling of Small Molecule Inhibitors Using µSPE Chip-based CE-MS with PRM-LIVE Acquisition on an Ion Mobility Mass Spectrometer
    Jarrod Marto
  • 01:15 Live Q&A

This session is sponsored by:    

01:30 - 03:00 (UTC)    Poster Viewing and Networking Time

03:00 - 04:15 (UTC)     Plenary Session 4 (PL04) - Proteomics-driven Precision Medicine

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

The promise of precision medicine aims to deliver customized medication to subgroups of patients based on molecular or cellular analysis. This section will highlight proteomics-driven translational studies with diagnostic and/or therapeutic impacts.

Chairs: Hanno Steen & Rob Rivers

  • 03:00 PL04.01 Proteomics-driven Precision Medicine
    Fuchu He
  • 03:30 PL04.02 Tackling Cancer Proteomic Heterogeneity Towards Early Diagnostics and Precision Medicine
    Tamar Geiger
  • 04:00 Live Q&A

This session is sponsored by:    

04:30 - 05:30 (UTC) Poster Session

Platform Location: Poster Sections 1 - 8

Poster presenters are available at their posters to present their work, chat with you and answer your questions.

View Full Poster List >>

05:45 - 06:45 (UTC)     HUPO General Assembly Session 2

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

This is the annual meeting for active HUPO members. HUPO members are encouraged to attend for society updates, Council election results, to ask questions and play a fun Kahoot proteomics quiz at the end. Winners of the Kahoot quiz receive a 3-year HUPO membership, while the runner-up receives a 1-year HUPO membership. Download the Kahoot app ahead of time, or you can join the quiz via https://kahoot.it/.

Chairs: Yu-Ju Chen, HUPO President and Henning Hermjakob, HUPO Secretary General

23:00 - 00:00 (UTC) Hot Topic Discussion 4: Metaproteomics

Platform Location: Education Sessions & Recordings | Hot Topic Room Metaproteomics

Metaproteomics – measuring the composite proteome from multiple organisms in a community — touches upon all aspects of conventional proteomics workflows, but much more intensely. Real or perceived challenges that are uniquely related to metaproteomics can create obstacles for newcomers to this endeavor. We will discuss these obstacles – ranging from sample acquisition and storage to instrumentation and computational complexities – and how to approach them for applications related to human health and environmental studies.

Discussants: Daniel Figeys, Robert Hettich, Mary Lipton

23:00 - 00:00 (UTC)     Hot Topic Discussion 5: Glycoproteomics Needs Glycobioinformatics

Platform Location: Education Sessions & Recordings | Hot Topic Room Glycoproteomics...

Recent developments in sample preparation, mass spectrometry and associated software tools facilitate the analysis of intact glycopeptides. However, bioinformatic tools for glycoproteomics are in their infancy compared to those available for more traditional proteomics, and considerable variation in performance metrics and interpretation currently exist among available tools and users. The lack of established guidelines and workflows for applying basic principles of glycobiology and tools for false-discovery rate estimation currently present challenges to accurate data reporting. In this session, experts in glycobiology and bioinformatics will discuss challenges and pose solutions to increase accuracy and reproducibility when interpreting mass spectrometry-based glycoproteomics data.

Moderator: Rebekah Gundry

Discussants: Frederique Lisacek, Robert Chalkley, Morten Andersen

23:00 - 00:00 (UTC)     Hot Topic Discussion 6: Top-down MS and Native Proteomics

Platform Location: Education Sessions & Recordings | Hot Topic Room Top-down MS...

This session will focus on current challenges, applicable solutions, and future directions of top-down MS and native proteomics. Several proposed topics include native top-down, data analysis/statistics/quantitation, and application/sample preparation in top-down proteomics. We will have an open and robust discussion between the audience and the discussants (panelists) after a brief introduction of each topic from the moderator/discussant.

Moderator: Si Wu

Discussants: Ljiljiana Pasa-Tolic, Ying Ge, Neil Kelleher, Joseph Loo

23:00 - 00:00 (UTC)     Hot Topic Discussion 7: Next Generation Proteomics Technologies: NGS, Microarray and Other Technology Platform Read Out

Platform Location: Education Sessions & Recordings | Hot Topic Room Next Generation Proteomics...

Discuss emerging proteomics technologies and their applications. What are the advantages and limitations of those technologies and future trending? What are the main application areas, what will be enabled by these technologies? How do these technologies add value to drug development pipelines?

Moderators: Fiona Kaper

Discussants: Towia Liberman, Carl Barrett, Adeeb Rahman

23:00 - 00:00 (UTC)     Hot Topic Discussion 8: The Human Proteome Project Grand Project – Advancing the Human Proteome

Platform Location: Education Sessions & Recordings | Hot Topic Room The Human Proteome Project...

Discussants: Charles Pineau, Gil Omenn, Robert Moritz, Ruedi Aebersold, Ileana Cristea, Cecilia Lindskog, Lydie Lane

00:15 - 01:30 (UTC)     Session 7 (KN07) - Proteomics Data Science and AI

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

Proteomics data science has developed from an appendix of data generation to the center stage, often requiring as much planning, time, and resources as the experimental component. This session will present current challenges and approaches, from proteogenomics to AI.

Chairs: Tiannan Guo & Kun-Hsing Yu

  • 00:15 KN07.01 Connecting Tumor Histopathology Images With Molecular Features Using Multi-Resolution Deep Learning Models
    David Fenyö
  • 00:35 KN07.02 Pride and Proteomexchange: Enabling “Big Data” Approaches in the Proteomics Field
    Juan Antonio Vizcaino
  • 00:55 KN07.03 Ionbot: A Novel, Innovative and Sensitive Machine Learning Approach to LC-MS/MS Peptide Identification
    Sven Degroeve
  • 01:05 KN07.04 Systematic Detection of Functional Proteoform Groups from Bottom-up Proteomic Datasets
    Isabell Bludau
  • 01:15 Live Q&A

01:30 - 03:00 (UTC)    Poster Viewing and Networking Time

03:00 - 04:15 (UTC)     Plenary Session 5 (PL05) - The Future of Proteomics

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

Proteomics is mature for system-wide measurement and quantification of protein expression levels, but also for comprehensive analyses at the single cell level. This session will highlight and discuss the future of proteomics and what is the place of the technology in precision medicine and precision health.

Chairs: Lennart Martens & Mathieu Lavallée-Adam

  • 03:00 PL05.01 Thoughts on the Future of Proteomics
    Mike Snyder
  • 03:30 PL05.02 Exploring Uncharted Facets of the Proteome
    Ruedi Aebersold
  • 04:00 Live Q&A

This session is sponsored by:     

04:30 - 05:30 (UTC)     Mentoring Session (MS03): Getting Started on Writing Manuscripts, Grants, and Fellowships

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

In addition to managing their daily lab work, young researchers are increasingly facing strenuous hurdles, such as maintaining a work-life balance, unclear career prospects, publication pressure, and writing blockades. Organized by HUPO’s Early Career Researcher Initiative in partnership with the European Proteomics Association’s Young Proteomics Investigators Club, the mentoring sessions extend the scope of HUPO ReCONNECT 2021 from pure science and technology to the topics that indirectly affect our research.

Chairs: Mio Iwasaki & Justyna Fert-Bober & Robert Rivers

Mentors: Yasushi Ishihama, Kyoto University | Rebekah L. Gundry, University of Nebraska | Zhengzheng Zhang, Molecular Omics Editor

This session is supported by:

05:45 - 06:45 (UTC)     Industry-Supported Seminar  (ISS10) - Bruker: Advances in 4D-Proteomics™: Single Cell Proteomics and PaSER Real-Time Search

Platform Location: Industry Hub | Industry Hub Auditorium 1

Please see here for more details.

07:00 - 08:30 (UTC)    Closing Ceremony & Award Lectures

Platform Location: Education Sessions & Recordings | Education Sessions Auditorium

  • 07:00 Congress Summary & Thank You
    Henning Hermjakob
  • 07:05 Announcement of Graduate Poster and ECR Manuscript Competition Winners
    Ruth Hüttenhain & Mathieu Lavallée-Adam
  • 07:15 Clinical & Translational Proteomics Sciences Award
    Ying Ge
  • 07:25 Discovery in Proteomic Sciences Award
    Paola Picotti
  • 07:35 Distinguished Achievement in Proteomic Sciences Award
    Nicolle H. Packer
  • 07:45 Distinguished Service Award
    Stephen Pennington
  • 07:55 Science & Technology Award
    Nicolai Bache & Ole Vorm
  • 08:10 HUPO 2022 Cancun Invite
  • 08:15 Closing Remarks
    Yu-Ju Chen

Pre-Congress Program (Nov. 8-12)

  • NOV 8
  • NOV 9
  • NOV 10
  • NOV 11
  • NOV 12

14:00 - 15:00 (UTC)     Pre-Congress Training (PT01): Proteomics 101

Characterization of complex proteomes is the key to reveal their composition and functions. This session will present an overview of the current methodology used to identify and quantify proteins. Three experts will cover the basic principles and practice of proteomics, analytical workflows and data interpretation of mass spectrometry based proteomics, global (isotopic labeling, label-free, DIA) and targeted quantitative proteomics methods [e.g., selected reaction monitoring (SRM) and parallel reaction monitoring (PRM)].

Chairs: Marc Wilkins & Maike Langini

14:00 Live Q&A with Chairs and Speakers

Watch the following pre-recorded presentations, available as of October 25 on the Virtual Platform in the Education Session Area. Recordings will not be played during the Live Session.

    • PT01.01 Introduction to Proteomics and Mass Spectrometry – Lindsay Pino
    • PT01.02 From Mass Spectrum to Protein – David Tabb
    • PT01.03 Quantitative and Targeted Proteomics – Michael MacCoss

14:00 - 15:00 (UTC)     Pre-Congress Training 2 (PT02): Statistics and Experimental Design

Tutorials covering statistics essential for proteomics experiments, and considerations for proteomics experimental design will be presented in this session. Attendees will learn the basics of designing a proteomics experiment for biological research and biomarker discovery, as well as issues related to analysing (large) quantitative proteomic data sets generated by data-dependent acquisition (DDA; including label-free and label-based-methods), data-independent acquisition (DIA), and targeted proteomics. The session will also cover the statistical principles for peptide and protein identification and quantification, taking into account the specific challenges of large data sets and cohorts.

Chairs: Tiannan Guo & Mathieu Lavallée-Adam

14:00 Live Q&A with Chairs and Speakers

Watch the following pre-recorded presentations, available as of October 25 on the Virtual Platform in the Education Session Area. They will not be played during the Live Session.

    • PT02.01 Statistical Considerations for Biomarker Discovery Experiments - Meena Choi
    • PT02.02 Statistics for Peptide and Protein Identification and Quantification - Alexey I. Nesvizhskii
    • PT02.03 Experimental Design and Data-analysis in Label-free Quantitative LC/MS Proteomics: A Tutorial with MSqRob - Lieven Clement

14:00 - 15:00 (UTC)     Pre-Congress Training (PT03): Interactomics Approaches

Proteins do not function in isolation, but rather, they associate with other proteins to form complexes and interaction networks with distinct structures and compositions to execute their function. Moreover, disease-causing genetic mutations may lead to alterations in protein function by modulating the interactions of the mutated proteins. Thus, a fundamental part of understanding a protein’s function in health and disease is to systematically study the proteins and other molecules that it interacts with and their dynamic changes in a cellular or disease state. Proteomics is the premier method for mapping protein-protein and protein-ligand interactions. This session will highlight approaches for the identification and characterization of protein-protein interactions and complexes.

Chairs: Ileana Cristea & Ruth Hüttenhain

14:00 Live Q&A with Chairs and Speakers

Watch the following pre-recorded presentations, available as of October 25 on the Virtual Platform in the Education Session Area. Recordings will not be played during the Live Session.

    • PT03.01 Thermal Protein Profiling - Mikhail M Savitski
    • PT03.02 Complex Centric Proteome Profiling - Isabel Bludeau
    • PT03.03 Protein-protein Interactions/Spatial Proteomics - Anne-Claude Gingras

16:00 - 19:00 (UTC)     Bioinformatics Hub

  • 16:00 Proteogenomics - Current State of the Art and Future Directions
    David Fenyö & Sam Payne
  • 17:00 ProteomeXchange - Current Status and Future Directions – Discussion
    Juan Antonio Vizcaíno
  • 17:30 Proteomics Standards Initiative - Ongoing Projects and Future Directions – Discussion
    Eric Deutsch & Dave Tabb
  • 18:00 Human Proteome Project - Human Proteins Absent from Swiss-Prot/neXtProt
    Sandra Orchard, Maria Martin, Gil Omenn
  • 18:30 Human Proteome Project - PE1 Validation with Protein-protein Interaction and Similar Data
    Sandra Orchard, Lydie Lane

20:00 - 23:00 (UTC)     BD-HPP Session - SARS-CoV-2 Through the Lens of Proteomics

  • 20:00 Introductory Remarks
  • 20:05 Peptide Vaccination for COVID19
    Speaker: Juliane Walz | Chair: Michal Bassani-Sternberg
  • 20:30 Insights from Mapping the HLA Class II-presented Peptidome of the SARS-CoV2 Spike Glycoprotein
    Speaker: Nicola Ternette | Chair: Maggie Lam
  • 20:55 Molecular Effects of SARS-CoV-2 Infections in a General and Undiagnosed Population
    Speaker: Jochen Schwenk | Chair: Fernando Corrales
  • 21:20 Sex Differences in Autoantibodies Response to SARS-CoV-2 Infection
    Speaker: Justyna Fert-Bober | Chair: Ileana Cristea
  • 21:45 Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor
    Speaker: Oliver Grant | Chair: Nicki Packer
  • 22:05 Drug-induced Phospholipidosis Confounds Drug Repurposing for SARS-CoV-2
    Speaker: Matthew O' Meara | Chair: Aleksandra Nita-Lazar
  • 22:30 Integrated Proteogenomic Characterization Across Seven Histological Types of Pediatric Brain Tumors
    Speaker: Francesca Petralia | Chair: Ferdinando Cerciello
  • 22:55 Concluding Remarks

10:00 - 12:00 (UTC)     Bioinformatics Hub

  • 10:00 Deep Learning in Proteomics
    Mathias Wilhelm & Cheng Chang & Wassim Gabriel
  • 11:00 EuBIC-MS: Ongoing Projects and Future Directions
    Tim Van Den Bossche & Ralf Gabriels & Julian Uszkoreit
  • 11:30 Tutorial: Proteomics in R
    Christian Panse & Tobias Kockmann

14:00 - 15:00 (UTC)    Pre-Congress Training 4 (PT04): Proteomics Informatics Workflows

Managing the informatics pipeline of a typical proteomics experiment is as important and challenging as managing the experimental and analytical workflows. This session will provide examples of large scale computational workflows for proteomics data management and analysis.

Chairs: Eric Deutsch & Cheng Chang

14:00    Live Q&A with Chairs and Speakers

Watch the following pre-recorded presentations, available as of October 25 on the Virtual Platform in the Education Session Area. Recordings will not be played during the Live Session.

    • PT04.01 MaxQuant and Perseus Workflows - Jürgen Cox
    • PT04.02 DIA Workflows -Brian Searle
    • PT04.03 ProteORE for Proteomics Data Interpretation in Galaxy -Yves Vandenbrouck

14:00 - 15:00 (UTC)     Pre-Congress Training 5 (PT05): Biological Context and Interpretation

Large-scale proteomics experiments generate an immense amount of data that need to be comprehensively interpreted to extract biological meaning after computational/statistical analyses are completed. This crucial step is required in order to select targets for functional follow-up which could take months to years of work. More specialized mass spectrometry-based experiments (such as interactome identification) also bring specific challenges for biological interpretation. This session will focus on use of large-scale datasets for elucidation of biological function, highlighting tools and strategies that can aid in these steps.

Chairs: Jennifer Geddes-McAlister & Andreas Hober

14:00 Live Q&A with Chairs and Speakers

Watch the following pre-recorded presentations, available as of October 25 on the Virtual Platform in the Education Session Area. They will not be played during the Live Session.

    • PT05.01 BioPlex 2.0 Project, Interactome - Ed Huttlin
    • PT05.02 HPA for Proteomics Data Interpretation - Cecilia Lindskog Bergström
    • PT05.03 (Large-scale) Multi-omics Data Analysis - Johannes Griss

14:00 - 15:20 (UTC)     HPP: Session 1 - HPP Project

Chair: Ileana Cristea

  • 14:00 The Human Proteome Project “Grand Project” A Function for Every Protein
    Robert Moritz, Chair HPP
  • 14:15 Translating Proteomics to the Clinical Arena
    Tom Montine
  • 14:35 The Pharma Proteomics Project
    Chris Whelan
  • 14:55 Target 2035 - Pharmacological Modulators for The Human Proteome Project “Grand Project”
    Cheryl Arrowsmith
  • 15:05 Expanding Proteomics Beyond the Proteomic Community with the Human Proteome Project “Grand Project” - Open Discussion
  • 15:15 Wrap up

16:00 - 17:40 (UTC)     HPP: Session 2 - Breakout Group Discussions

Chair: Fernando Corrales

  • 16:00 Questions for Each of the Breakout Session
  • 16:05 Breakout Sessions
      • Breakout I - Scientific Advisory Board session - Ruedi Aebersold
      • Breakout II - Pathology Pillar “Clinical relevance of the Grand Project” - Michael Roehrl
      • Breakout III - Chromosome Centric-HPP “Providing Evidence to Function” – Chris Overall
      • Breakout IV - Biology/Disease-HPP “Organizing Functional Consequences” - Ileana Cristea
      • Breakout V - MS Pillar/Knowledgebase Pillar/Antibody Pillar – Contribution of Pillars to the Grand Project - Susan Weintraub, Eric Deutsch, Cecilia Lindskog
  • 16:50 Summary - Reports

18:00 - 19:40 (UTC)     HPP: Session 3 - Progress and Plans

Chair: Susan Weintraub

  • 18:00 Review and Updates from 2021 (Outcomes and Developments)
      • C-HPP - Chris Overall
      • B/D-HPP - Ileana Cristea
      • Resource Pillar: Ab - Cecilia Lindskog
      • Resource Pillar: KB - Eric Deutsch & Nuno Bandeira & Lydie Lane
      • Resource Pillar: PP - Michael Roehrl & Ed Nice
      • Resource Pillar: MS - Susan Weintraub
  • 18:30 ECR Involvement in HPP and the Grand Challenge
    Ferdinando Cerciello 
  • 18:40 Open Session – Grand Project Discussion
  • 19:00 Other Opportunities – Questions from Floor
  • 19:10 Final Summary
    Rob Moritz
  • 19:15 Incoming HPP Chair Address
    Charles Pineau
  • 19:25 Closing Address
    Rob Moritz & Ruedi Aebersold

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